Craig Fitzgibbon has made the biggest calls of his coaching career by dropping five-eighth Matt Moylan, relegating representative centre Siosifa Talakai to the bench and picking a six-game rookie in the back row.
Co-captain Wade Graham is also out of the Sharks line-up for a crucial home clash against Manly at PointsBet Stadium on Sunday.
Graham has been ruled out with a toe injury.
The sweeping changes from Fitzgibbon include the promotion of NSW Cup playmaker Braydon Trindall into the halves for Moylan, Connor Tracey into the centres for Talakai and 21-year-old Wollongong-product Jesse Colquhoun named to make his starting debut in the back row for the injured Teig Wilton (knee).
Wilton has suffered a meniscus-related injury to his knee and will meet with specialists this week to determine his road to recovery.
SCROLL DOWN TO SEE ALL THE CHANGES AHEAD OF ROUND 21
Fed-up with the sixth-placed Sharks’ leaky defence, Fitzgibbon has named vitrually new left-edge with winger Ronaldo Mulitalo the only survivor of the Sharks’ 44-12 loss to the Warriors on Sunday.
It’s a brave call from Fitzgibbon to rip-up the combinations that have enabled the Sharks to become the second-best attacking side in the NRL.
In further changes, co-captain Dale Finucane returns from suspension while Royce Hunt (ankle) is also expected to be named in the extended reserves and could be a late inclusion.
DRAGONS v TIGERS
Thursday, 7:50pm, WIN Stadium, Wollongong
Dragons
1. Tyrell Sloan 2. Mathew Feagai 3. Moses Suli 4. Zac Lomax 5. Mikaele Ravalawa 6. Talatau Amone 7. Ben Hunt 8. Francis Molo 9. Jacob Liddle 10. Blake Lawrie 11. Billy Burns 12. Dan Russell 13. Jack de Belin
Bench: 14. Moses Mbye 15. Michael Molo 16. Toby Couchman 17. Jack Bird
Reserves: 18. Zane Musgrove 19 Sione Finau 20. Ryan Couchman 21. Max Feagai 22. Jaiyden Hunt
Tigers
1. Jahream Bula 2. David Nofoaluma 3. Starford To’a 4. Tommy Talau 5. Junior Tupou 6. Daine Laurie 7. Brandon Wakeham 8. Stefano Utoikamanu 9. Apisai Koroisau 10. David Klemmer 11. Isaiah Papali’i 12. John Bateman 13. Shawn Blore
Bench: 14. Tallyn Da Silva 15. Fonua Pole 16. Alex Seyfarth 17. Alex Twal
Interchange: 18. Aitasi James 19. Jake Simpkin 20. Will Smith 21. Asu Kepaoa 22. Justin Matamua
WARRIORS v RAIDERS
Friday, 6pm, Go Media Stadium, Auckland
Warriors
1. Charnze Nicoll-Klokstad 2. Dallin Watene-Zelezniak 3. Rocco Berry 4. Adam Pompey 5. Marcelo Montoya 6. Luke Metcalf 7. Shaun Johnson 8. Addin Fonua-Blake 9. Wayde Egan 10. Bunty Afoa 11. Jackson Ford 12. Marata Niukore 13. Tohu Harris
Bench: 14. Dylan Walker 15. Mitchell Barnett 16. Tom Ale 17. Freddy Lussick
Interchange: 18. Bayley Sironen 20. Josh Curran 21. Ronald Volkman 22. Taine Tuaupiki 23. Viliami Vailea
Raiders
1. Sebastian Kris 2. Albert Hopoate 3. Jarrod Croker 4. Matthew Timoko 5. Jordan Rapana 6. Jack Wighton 7. Jamal Fogarty 8. Josh Papali’i 9. Zac Woolford 10. Joseph Tapine 11. Hudson Young 12. Elliott Whitehead 13. Corey Horsburgh
Bench: 14. Tom Starling 15. Emre Guler 16. Pasami Saulo 17. Ata Mariota
Interchange: 18. Matt Frawley 19. Nick Cotric 20. Trey Mooney 21. Hohepa Puru 22. Ethan Strange
RABBITOHS v BRONCOS
Friday, 8pm, Sunshine Coast Stadium, Sunshine Coast
Rabbitohs
1. Latrell Mitchell 2. Alex Johnston 3. Isaiah Tass 4. Campbell Graham 5. Taane Milne 6. Cody Walker 7. Lachlan Ilias 8. Tevita Tatola 9. Damien Cook 10. Hame Sele 11. Keaon Koloamatangi 12. Jai Arrow 13. Cameron Murray
Bench: 14. Blake Taaffe 15. Siliva Havili 16. Thomas Burgess 17. Jacob Host
Interchange: 18. Jed Cartwright 19. Tallis Duncan 20. Peter Mamouzelos 21. Davvy Moale 22. Dean Hawkins
Broncos
1. Reece Walsh 2. Jesse Arthars 3. Kotoni Staggs 4. Herbie Farnworth 5. Selwyn Cobbo 6. Ezra Mam 7. Adam Reynolds 8. Keenan Palasia 9. Billy Walters 10. Payne Haas 11. Kurt Capewell 12. Brendan Piakura 13. Patrick Carrigan
Bench: 14. Tyson Smoothy 15. Corey Jensen 16. Kobe Hetherington 17. Martin Taupau
Interchange: 18. Deine Mariner 19. Jock Madden 20. Xavier Willison 21. Tristan Sailor 22. Delouise Hoeter
TITANS v ROOSTERS
Saturday, 3pm, Cbus Super Stadium, Gold Coast
Titans
1. AJ Brimson 2. Alofiana Khan-Pereira 3. Brian Kelly 4. Jojo Fifita 5. Phillip Sami 6. Kieran Foran 7. Tanah Boyd 8. Moeaki Fotuaika 9. Sam Verrills 10. Isaac Liu 11. David Fifita 12. Klese Haas 13. Erin Clark
Bench: 14. Jayden Campbell 15. Chris Randall 16. Joe Stimson 17. Jacob Alick
Interchange: 18. Iszac Fa’asumaleaui 19. Aaron Schoupp 20. Ken Maumalo 21. Kruise Leeming 22. Thomas Mikaele
Roosters
1. James Tedesco 2. Daniel Tupou 3. Billy Smith 4. Joseph Manu 5. Joseph-Aukuso Suaalii 6. Luke Keary 7. Sandon Smith 8. Jared Waerea-Hargreaves 9. Jake Turpin 10. Lindsay Collins 11. Victor Radley 12. Nat Butcher 13. Nathan Brown
Bench: 14. Brandon Smith 15. Egan Butcher 16. Siua Wong 17. Terrell May
Interchange: 18. Corey Allan 19. Dylan Napa 20. Drew Hutchison 21. Fetalaiga Pauga 22. Fletcher Baker
KNIGHTS v STORM
Saturday, 5:30pm, McDonald Jones Stadium, Newcastle
Knights
1. Kalyn Ponga 2. Dominic Young 3. Dane Gagai 4. Bradman Best 5. Greg Marzhew 6. Tyson Gamble 7. Jackson Hastings 8. Daniel Saifiti 9. Phoenix Crossland 10. Leo Thompson 11. Tyson Frizell 12. Lachlan Fitzgibbon 13. Adam Elliott
Bench: 14. Kurt Mann 15. Jacob Saifiti 16. Jack Hetherington 17. Mathew Croker
Reserves: 18. Dylan Lucas 19. Enari Tuala 20. Brodie Jones 21. Hymel Hunt 22. Adam Clune
Storm
1. Nick Meaney 2. William Warbrick 3. Reimis Smith 4. Justin Olam 5. Xavier Coates 6. Cameron Munster 7. Jahrome Hughes 8. Tui Kamikamica 9. Harry Grant 10. Christian Welch 11. Trent Loiero 12. Nelson Asofa-Solomona 13. Josh King
Bench: 14. Tyran Wishart 15. Tom Eisenhuth 16. Tariq Sims 17. Alec MacDonald
Reserves: 18. Bronson Garlick 19. Chris Lewis 20. Jayden Nikorima 21. Marion Seve 22. 23. George Jennings
COWBOYS v EELS
Saturday, 7:35pm, QCB Stadium, Townsville
Cowboys
1. Scott Drinkwater 2. Semi Valemei 3. Valentine Holmes 4. Peta Hiku 5. Murray Taulagi 6. Tom Dearden 7. Chad Townsend 8. Jordan McLean 9. Reece Robson 10. Coen Hess 11. Luciano Leilua 12. Jeremiah Nanai 13. Reuben Cotter
Bench: 14. Jake Granville 15. Griffin Neame 16. Jason Taumalolo 17. Kulikefu Finefeuiaki
Reserves: 18. Zac Laybutt 19. Jamayne Taunoa-Brown 20. Sam McIntyre 21. Ben Hampton 22. Mitchell Dunn
Eels
1. Clinton Gutherson 2. Maika Sivo 3. Viliami Penisini 4. Bailey Simonsson 5. Sean Russell 6. Daejarn Asi 7. Mitchell Moses 8. Ofahiki Ogden 9. Brendan Hands 10. Junior Paulo 11. Shaun Lane 12. Bryce Cartwright 13. J’maine Hopgood
Bench: 14. Luca Moretti 15. Joe Ofahengaue 16. Andrew Davey 17. Ryan Matterson
Reserves: 18. Haze Dunster 19. Makahesi Makatoa 20. Waqa Blake 21. Ky Rodwell 22. Jack Murchie
PANTHERS v BULLDOGS
Sunday, 2pm, BlueBet Stadium, Penrith
Panthers
1. Dylan Edwards 2. Sunia Turuva 3. Izack Tago 4. Stephen Crichton 5. Brian To’o 6. Jarome Luai 7. Nathan Cleary 8. Moses Leota 9. Mitch Kenny 10. James Fisher-Harris 11. Scott Sorensen 12. Liam Martin 13. Isaah Yeo
Bench: 14. Soni Luke 15. Lindsay Smith 16. Spencer Leniu 17. Luke Garner
Reserves: 18. Jack Cogger 19. Matt Eisenhuth 20. Jaeman Salmon 21. Tom Jenkins 22. Tyrone Peachey
Bulldogs
1. Jake Averillo 2. Blake Wilson 3. Jacob Kiraz, 4. Paul Alamoti 5. Jeral Skelton 6. Matt Burton 7. Kyle Flanagan 8. Max King 9. Reed Mahoney 10. Raymond Faitala-Mariner 11. Jackson Topine 12. Jacob Preston 13. Corey Waddell
Bench: 14. Harrison Edwards 15. Kurtis Morrin 16. Tevita Pangai Junior 17. Jayden Okunbor
Reserves: 19. Samuel Hughes, 20. Hayze Perham 21. Chris Patolo 22. Josh Addo-Carr 23. Viliame Kikau
SHARKS v SEA EAGLES
Sunday, 4:05pm, PointsBet Stadium, Sydney
Sharks
1. William Kennedy 2. Sione Katoa 3. Jesse Ramien 4. Connor Tracey 5. Ronaldo Mulitalo 6. Braydon Trindall 7. Nicho Hynes 8. Oregon Kaufusi 9. Blayke Brailey 10. Toby Rudolf 11. Briton Nikora 12. Jesse Colquhoun 13. Dale Finucane
Bench: 14. Cameron McInnes 15. Siosifa Talakai 16. Jack Williams 17. Thomas Hazelton
Reserves: 18. Kayal Iro 19. Mawene Hiroti 20. Royce Hunt 21. Daniel Atkinson 22. Tuku Hau Tapuha
Sea Eagles
1. Reuben Garrick 2. Jason Saab 3. Brad Parker 4. Tolutau Koula 5. Christian Tuipulotu 6. Josh Schuster 7. Daly Cherry-Evans 8. Taniela Paseka 9. Lachlan Croker 10. Josh Aloiai 11. Haumole Olakau’atu 12. Kelma Tuilagi 13. Jake Trbojevic
Bench: 14. Dean Matterson 15. Aaron Woods 16. Sean Keppie, 17. Matthew Lodge
Reserves: 18. Ethan Bullemor 19. Jake Arthur, 20. Toafofoa Sipley 21. Ray Tuaimalo-Vaega 22. Gordon Chan Kum Tong
BYE: Dolphins